Researchers find new role for cannabinoids in vision Featured

Biological and Medical Sciences Written by  mardi, 15 novembre 2016 18:11 font size decrease font size increase font size
{JFBCLike}{SCGooglePlusOne}{JLinkedShare}{SCTwitterShare}
11
Rate this item
(0 votes)

A multidisciplinary team including researchers from the Montreal Neurological Institute has improved our understanding of how cannabinoids, the active agent in marijuana, affect vision in vertebrates.

Scientists used a variety of methods to test how tadpoles react to visual stimuli when they’ve been exposed to increased levels of exogenous or endogenous cannabinoids. Exogenous cannabinoids are artificially introduced drugs, whereas endogenous cannabinoids occur naturally in the body.

They found that, contrary to what they expected, activating cannabinoid signaling in tadpoles actually increased the activity in their retinal ganglion cells (RGCs), which are responsible for transmitting information about light detection from the eye to the brain. Previous studies found that cannabinoids typically work to reduce neurotransmission, not increase it.

“Initially you distrust yourself when you see something that goes against widely held ideas, but we tried the experiment so many times, using diverse techniques, and it was a consistent result,” says Ed Ruthazer, a professor of neurology and neurosurgery at the Montreal Neurological Institute of McGill University, and the paper’s senior author. “So then we knew we had to figure out what was going on. The first tendency is to want to ignore it. But it was such a strong effect, we knew there was something important here.”

What the researchers found is that one class of cannabinoid receptor, known as CB1R, plays a role in the suppression of chloride transport into the RGCs. When the receptor is activated, chloride levels are reduced, which hyperpolarizes the cell, making it able to fire at higher frequencies when stimulated.

For the tadpoles, this meant they were able to detect dimmer objects in low light than when they had not been exposed to increased levels of cannabinoids. The team used software developed with McGill physics and chemistry professor Paul Wiseman to detect behavior changes in the tadpoles.

It is too early to say if cannabinoids have the same effect on human vision, but there is anecdotal evidence in scientific literature of cannabis ingestion improving night vision of Jamaican and Moroccan fishermen.

What’s more interesting however, according to Ruthazer, is that they have discovered a previously unknown role for cannabinoids in brain signaling. Therapeutic use of cannabinoids is becoming increasingly accepted by the medical community, and the need for an accurate and thorough understanding of these chemicals’ role in the brain is greater than ever.

“Our work provides an exciting potential mechanism for cannabinoid regulation of neuronal firing, but it will obviously be important to confirm that similar mechanisms are also at play in the eyes of mammals,” says Ruthazer. “Though technically more challenging, a similar study should now be performed in the mouse retina or even in cultures of human retinal cells.”

Source

Read 66980 times Last modified on mardi, 15 novembre 2016 18:18

11 comments

  • Comment Link Tamie vendredi, 07 février 2020 04:36 posted by Tamie

    My brother suggested I may like this web site.
    He was once entirely right. This put up truly made my day.
    You can not believe simply how so much time I had spent for
    this information! Thank you!

    Report
  • Comment Link Santiago mercredi, 05 février 2020 02:36 posted by Santiago

    Have you ever considered writing an ebook or guest authoring on other websites?
    I have a blog centered on the same subjects you discuss and would love to have you share some stories/information. I know my
    audience would enjoy your work. If you are even remotely interested, feel
    free to shoot me an e-mail.

    Report
  • Comment Link Maude dimanche, 26 janvier 2020 19:50 posted by Maude

    I know this if off topic but I'm looking into starting my own blog and was curious what all is needed to
    get setup? I'm assuming having a blog like yours would cost
    a pretty penny? I'm not very web smart so
    I'm not 100% sure. Any suggestions or advice would be greatly appreciated.
    Appreciate it

    Report
  • Comment Link Israel vendredi, 17 janvier 2020 17:51 posted by Israel

    Hey! Someone in my Myspace group shared this website with
    us so I came to give it a look. I'm definitely loving
    the information. I'm bookmarking and will be tweeting this to my followers!
    Exceptional blog and superb style and design.

    Report
  • Comment Link demenagement-montroyal jeudi, 25 juillet 2019 12:47 posted by demenagement-montroyal

    It?s the best time to make some plans for
    the future and it?s time to be happy.
    I have read this post and if I could I want to suggest
    you few interesting things or advice. Maybe you can write next articles referring to this article.

    I wish to read more things about it! https://demenagement-montroyal.com

    Report
  • Comment Link Hidden Gems-Agence mardi, 28 mai 2019 22:08 posted by Hidden Gems-Agence

    Thank you for writing this awesome article! I subscribed to your blog and shared this on my Twitter.
    Thanks for a great article! https://hiddengemsta.com

    Report
  • Comment Link Ellie dimanche, 26 mai 2019 05:50 posted by Ellie

    Представляем Вам нашу нашу коллекцию порно фотографий на сайте - канал .
    Смотри как стройные красавицы модельной внешности позируют перед камерой демонстрируя свои
    "прелести". Только самые страстные девушки
    готовые на все. Кстати, у нас ты найдешь не только гламурыне потрно фотки, но и
    необычные фото, так сказать на любителя, с разныеми фетишами и фистингом.
    Все фото архивы разбиты по категориям, выбирай понравишуюся и смотри совершенно
    бесплатно!
    http://imagenetofficesystems.net/__media__/js/netsoltrademark.php?d=trello.com%2Fadd-card%3Fdesc%3Dhttps%3A%2F%2Fseks-pics.ru

    Report
  • Comment Link Yoma Life samedi, 04 mai 2019 05:44 posted by Yoma Life

    Hi there, just wanted to say, I loved this article.

    It was helpful. Keep on posting! https://www.yoma.life

    Report
  • Comment Link L M Esthetique Elle  Lui mercredi, 24 avril 2019 13:43 posted by L M Esthetique Elle Lui

    A person necessarily
    help to make significantly posts
    I might state. This is the first time I frequented your website page and to this point?
    I amazed with the research you made to create this particular
    publish incredible. Great job!|
    Heya i am for the primary time here. https://www.lmesthetique.ca/soins-corps/

    Report
  • Comment Link custom t shirt quick mardi, 15 janvier 2019 20:56 posted by custom t shirt quick

    I used to be able to find good information from your blog posts.

    Report

Leave a comment

Make sure you enter all the required information, indicated by an asterisk (*). HTML code is not allowed.

Arabways Newsletter

Sign up to our newsletter

  

Recent Twitter Posts

Membership

The main criterion for election as a ARABWAYS Member is scientific excellence. Only those scientists who have made significant contributions to the advancement of science can be nominated as Members

Becoming a member is easy! Just make sure you have all of the items listed below :

  • Curriculum Vitae/Resume
  • Students and Postdocs: Proof of enrollment/status such as letter of acceptance and contact information for a department/faculty contact. 
  • Membership form